Overview

CGP77675 is a potent inhibitor of Src family kinases. It has been reported to inhibit phosphorylation of peptide substrates and autophosphorylation of purified Src (IC₅₀ = 5 - 20 nM and 40 nM, respectively), Src, and Src kinase family members such as LCK (IC₅₀ = 0.02 mM and 0.29 mM, respectively). It has also been shown to inhibit epidermal growth factor receptor (EGFR), Cdc2, v-Abl, and focal adhesion kinase (FAK) (IC₅₀ = 0.15 mM, > 10 mM, 0.31 mM, and 0.2 mM, respectively; Missbach et al.).MAINTENANCE AND SELF-RENEWAL· In combination with the GSK3 inhibitor CHIR99021 (Catalog #72052), CGP77675 is used to maintain mouse embryonic stem (ES) cells (Shimizu et al.).· Preserves the epigenetic and genomic integrity as well as the developmental potential of ES cells (Choi et al.).

Alternative Names:

Not applicable

CAS Number:

234772-64-6

Chemical Formula:

C₂₆H₂₉N₅O₂

Molecular Weight:

443.5 g/mol

Purity:

≥ 98%

Target:

EGFR; LCK; SRC

品牌介绍

STEMCELL

STEMCELL Technologies 成立于 1993 年,是加拿大最大的生物科技公司,为生命科学研究领域提供专业的细胞培养基和细胞分选产品。

STEMCELL Technologies Inc. is a Canadian biotechnology company that develops specialty cell culture media, cell isolation systems and accessory products for life science research. Driven by science and a passion for quality, STEMCELL supports the advancement of scientific research around the world with our catalogue of more than 2000 cell biology research tools.

产品列表：

No.	品牌	货号	名称	规格
1	stemcell	60026	Anti-Dextran Antibody, Clone DX1	100ug
2	stemcell	60012	Anti-Human CD32 Antibody, Clone IV.3	100ug
3	stemcell	60004PE.1	Anti-Human CD14 Antibody, Clone M5E2	25tests
4	stemcell	60005AD	Anti-Human CD19 Antibody, Clone HIB19	100tests
5	stemcell	60018AD.1	Anti-Human CD45 Antibody, Clone HI30	25tests
6	stemcell	02002	Human IFN-gamma ELISA Kit	2plates
7	stemcell	02006	Human IL-2 ELISA Kit	2plates
8	stemcell	02012	Human IL-10 ELISA Kit	2plates
9	stemcell	02020	Mouse IFN-gamma ELISA Kit	2plates
10	stemcell	02030	Mouse TNF-alpha ELISA Kit	2plates
11	stemcell	01630	Erythropoietin (EPO) ELISA Kit	1kit
12	stemcell	27000	STEMgrid™-6	1grid
13	stemcell	27270	Reversible Strainers	25/box
14	stemcell	27100	35 mm Culture Dishes	10dishes
15	stemcell	20125	RoboSep™Filter Tips	8racks