Overview

Amphiregulin is a member of the epidermal growth factor (EGF) family. It binds to several receptors including EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3, and HER4/ErbB4, which activates Ras/Raf/MAPK and PI3K/AKT pathways. This results in cell proliferation, apoptosis resistance, and invasive behaviour (Normanno et al.). The expression of amphiregulin is induced by tissue injury and inflammation. Amphiregulin promotes mammary development, trophoblast growth, lung and kidney branching morphogenesis, and keratinocyte proliferation. It stimulates the growth of most cell types, including normal and transformed mammary epithelial cells, and malignant cells of the colon, prostate, cervix, and pancreas (Berasain & Avila).

Alternative Names:

AR, AREG, AREGB, Colorectum cell-derived growth factor, CRDGF, MGC13647, Schwannoma-derived growth factor, SDGF

Cell Type:

Mammary Cells; Airway Cells

Species:

Human

Area of Interest:

Epithelial Cell Biology

Molecular Weight:

11.3 kDa

Purity:

≥ 95%

品牌介绍

STEMCELL

STEMCELL Technologies 成立于 1993 年,是加拿大最大的生物科技公司,为生命科学研究领域提供专业的细胞培养基和细胞分选产品。

STEMCELL Technologies Inc. is a Canadian biotechnology company that develops specialty cell culture media, cell isolation systems and accessory products for life science research. Driven by science and a passion for quality, STEMCELL supports the advancement of scientific research around the world with our catalogue of more than 2000 cell biology research tools.

产品列表：

No.	品牌	货号	名称	规格
1	stemcell	60026	Anti-Dextran Antibody, Clone DX1	100ug
2	stemcell	60012	Anti-Human CD32 Antibody, Clone IV.3	100ug
3	stemcell	60004PE.1	Anti-Human CD14 Antibody, Clone M5E2	25tests
4	stemcell	60005AD	Anti-Human CD19 Antibody, Clone HIB19	100tests
5	stemcell	60018AD.1	Anti-Human CD45 Antibody, Clone HI30	25tests
6	stemcell	02002	Human IFN-gamma ELISA Kit	2plates
7	stemcell	02006	Human IL-2 ELISA Kit	2plates
8	stemcell	02012	Human IL-10 ELISA Kit	2plates
9	stemcell	02020	Mouse IFN-gamma ELISA Kit	2plates
10	stemcell	02030	Mouse TNF-alpha ELISA Kit	2plates
11	stemcell	01630	Erythropoietin (EPO) ELISA Kit	1kit
12	stemcell	27000	STEMgrid™-6	1grid
13	stemcell	27270	Reversible Strainers	25/box
14	stemcell	27100	35 mm Culture Dishes	10dishes
15	stemcell	20125	RoboSep™Filter Tips	8racks